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Es ist auch umgekehrt der Fall: Wenn Mitochondrien geschwcht sind, tragen sie zur Entstehung chronischer Erkrankungen bei

HG-induced iron overload generates hydroxyl radicals, causing mitochondrial membrane potential (MMP) depolarization, mtDNA damage, and dysfunction ( 3.3.5 Antioxidant proteins as potential therapeutic targets for ferroptosis in DN Ferroptosis in DN is governed by a core network of antioxidant proteins, with Nrf2 as the master transcriptional regulator